Nature Chemistry

Catalyst recognition of cis-1, 2-diols enables site-selective functionalization of complex molecules

X Sun, H Lee, S Lee, KL Tan

Index: Sun, Xixi; Lee, Hyelee; Lee, Sunggi; Tan, Kian L. Nature Chemistry, 2013 , vol. 5, # 9 p. 790 - 795

Full Text: HTML

Citation Number: 6

Abstract

Carbohydrates and natural products serve essential roles in nature, and also provide core scaffolds for pharmaceutical agents and vaccines. However, the inherent complexity of these molecules imposes significant synthetic hurdles for their selective functionalization and derivatization. Nature has, in part, addressed these issues by employing enzymes that are able to orient and activate substrates within a chiral pocket, which increases dramatically ...

Related Articles:

Universal solid supports for the synthesis of oligonucleotides via a transesterification of H-phosphonate diester linkage

[Wang, Weimin; Song, Quanlai; Jones, Roger A. Tetrahedron Letters, 1999 , vol. 40, # 51 p. 8971 - 8974]

Nitrate ion as catalyst for selective silylations of nucleosides

[Hakimelahi, Gholam H.; Proba, Zbigniew A.; Ogilvie, Kelvin K. Tetrahedron Letters, 1981 , vol. 22, # 48 p. 4775 - 4778]

More Articles...