Studies on the acetylation of 3, 6??diamino??1H??pyrazolo [3, 4??b] pyridine??5??carbonitrile derivatives

…, A Samadi, J Marco??Contelles

Index: Chioua, Mourad; Soriano, Elena; Samadi, Abdelouahid; Marco-Contelles Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 4 p. 861 - 872

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Citation Number: 8

Abstract

The pyrazolo [3, 4-b] pyridine ring system [1] is present in a number of pharmaceutically important compounds targeted to inhibit VEGFR/PDGFR kinases [2] or GSK-3 [3]. In a current project aimed at the synthesis, design, and biological evaluation of new GSK-3 inhibitors, we have recently synthesized a series of known and new 3, 6-diamino-1H- pyrazolo [3, 4-b] pyridines [4](A)(Chart 1). To carry out basic SAR studies, we decided to ...