Novel 1-oxyl-2-substitutedphenyl-4, 4, 5, 5-tetramethylimidazolines: Synthesis, selectively analgesic action, and QSAR analysis

…, L Peng, YR Tang, C Wang, Z Zhang, S Peng

Index: Zhao, Ming; Li, Zheng; Peng, Li; Tang, Yu-Rong; Wang, Chao; Zhang, Ziding; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 2815 - 2826

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Citation Number: 12

Abstract

Based on the knowledge that imidazoline can result in analgesic action due to its selective binding with the prostacyclin receptor, 20 1-oxyl-2-substitutedphenyl-4, 4, 5, 5- tetramethylimidazolines (3a–t) were prepared in moderate yields. At 0.13 mmol/kg dose, their in vivo analgesic activities were evaluated after the mice were administered at 30, 60, 90, and 150min. Compared with the pain threshold (12.27±9.56–17.71±7.00%) of normal ...