β N O Turns and Helices Induced by β2??Aminoxy Peptides: Synthesis and Conformational Studies

…, XW Chang, W Ding, GJ Liu, KS Song…

Index: Jiao, Zhi-Gang; Chang, Xiao-Wei; Ding, Wei; Liu, Guo-Jun; Song, Ke-Sheng; Zhu, Nian-Yong; Zhang, Dan-Wei; Yang, Dan Chemistry - An Asian Journal, 2011 , vol. 6, # 7 p. 1791 - 1799

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Citation Number: 6

Abstract

Abstract Herein, we report an efficient route for the asymmetric synthesis of β 2-aminoxy acids as well as experimental and theoretical studies of conformations of peptides composed of β 2-aminoxy acids. The nine-membered-ring intramolecular hydrogen bonds, namely, β N [BOND] O turns, are generated between adjacent residues in those peptides, in accordance with our computational results. The presence of two consecutive homochiral β ...