Polypeptides. Part XXI. Synthesis of some sequential macromolecular polypeptolides of L-leucine and L-2-hydroxy-4-methylpentanoic acid

B Ridge, HN Rydon, CR Snell

Index: Ridge; Rydon; Snell Journal of the Chemical Society. Perkin transactions 1, 1972 , vol. 16, p. 2041 - 2046

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Citation Number: 6

Abstract

Four protected oligopeptolides of L-leucine and L-2-hydroxy-4-methylpentanoic acid, with benzyloxycarbonyl as N-protecting and t-butyl as C-protecting group, have been synthesised; the depside linkage was formed by the action of dicyclohexylcarbodi-imide in ethereal pyridine. The action of triethylamine on the chloride hydrochlorides of the deprotected oligopeptolides gave the macromolecular sequential polypeptolides (I; x= 1, 2 ...

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