Uptake into mouse brain of four compounds present in the psychoactive beverage kava

J Keledjian, PH Duffield, DD Jamieson…

Index: Keledjian; Duffield; Jamieson; Lidgard Journal of Pharmaceutical Sciences, 1988 , vol. 77, # 12 p. 1003 - 1006

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Citation Number: 68

Abstract

Abstract A technique using gas chromatography–mass spectrometry and deuterated internal standards is described for the quantitation in brain tissue of four constituents of the intoxicating beverage kava. Dihydrokawain, kawain, desmethoxyyangonin, and yangonin were administered ip to mice at a dosage of 100 mg/kg. At specific time intervals (5, 15, 30, and 45 min), the mice were sacrificed and the brain concentrations of these four ...

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