European journal of medicinal chemistry

Comparative study of microtubule inhibitors–estramustine and natural podophyllotoxin conjugated PAMAM dendrimer on glioma cell proliferation

UH Sk, D Dixit, E Sen

Index: Sk, Ugir Hossain; Dixit, Deobrat; Sen, Ellora European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 47 - 57

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Citation Number: 7

Abstract

Abstract The synthetic estramustine (EM) and natural podophyllotoxin (PODO) anti-mitotic agents that inhibit tubulin polymerization are known anticancer agents. As low bioavailability limits their anticancer properties, we investigated whether conjugation with PAMAM ...