Facile Production of D-Histidine by Asymmetric Transformation of L-Histidine.

…, K Shinjo, Y Masui, A Ohta, H Natsuyama…

Index: Shiraiwa, Tadashi; Shinjo, Kazuyuki; Masui, Yoko; Ohta, Atsushi; Natsuyama, Hisashi; et. al. Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 12 p. 3741 - 3742

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Citation Number: 8

Abstract

抄録 An asymmetric transformation from L-histidine [L-His] to D-His was achieved by using salicylaldehyde as a catalyst for epimerization, and (2< I> R, 3< I> R)-tartaric acid as a resolving agent, in acetic acid. Treatment of the obtained salt with triethylamine in methanol gave D-His with 100% optical purity in 95% yield based on the starting L-His.