Synthesis of UDP-glucose derivatives modified at the 3-OH as potential chain terminators of β-glucan biosynthesis

R Danac, L Ball, SJ Gurr, AJ Fairbanks

Index: Danac, Ramona; Ball, Lucy; Gurr, Sarah J.; Fairbanks, Antony J. Carbohydrate Research, 2008 , vol. 343, # 6 p. 1012 - 1022

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Citation Number: 19

Abstract

A series of UDP-d-glucose derivatives and precursors that have been modified at C-3 were synthesised from d-glucose as potential chain terminators of β-glucan biosynthesis. None of the UDP-derivatives or the precursors tested displayed significant anti-fungal activity in a series of germination assays on the dermatophyte Trichophyton rubrum.