A thorough study of the stereochemical consequences of the hydration/dehydration reaction catalyzed by. beta.-hydroxydecanoyl thioester dehydrase
JM Schwab, A Habib, JB Klassen
Index: Schwab, John M.; Habib, Asif; Klassen, John B. Journal of the American Chemical Society, 1986 , vol. 108, # 17 p. 5304 - 5308
Full Text: HTML
Citation Number: 17
Abstract
Abstract: 8-Hydroxydecanoyl thioester dehydrase is the pivotal enzyme in the biosynthesis of unsaturated fatty acids under anaerobic conditions, catalyzing the equilibration of thioesters of (R)-3-hydroxydecanoic acid,(E)-2-decenoic acid, and (Z)-3-decenoic acid. Substrates chirally labeled with deuterium have been synthesized and incubated with dehydrase. Analysis of labeled products by* H NMR spectroscopy has shown that the pro- ...
Related Articles:
[Duffault, Jean-Marc; Hanoteau, Pascal; Parrilla, Alfredo; Einhorn, Jacques Synthetic Communications, 1996 , vol. 26, # 17 p. 3257 - 3265]
[Makra, Ferenc; Rohloff, John C.; Muehldorf, A. V.; Link, John O. Tetrahedron Letters, 1995 , vol. 36, # 38 p. 6815 - 6818]