Total Synthesis of the Biphenomycins; II. 1 Synthesis of Protected (2S, 4R)-4-Hydroxyornithines

…, R Meyer, V Leitenberger, F Stäbler, A Lieberknecht

Index: Schmidt; Meyer; Leitenberger; Stabler; Lieberknecht Synthesis, 1991 , # 5 p. 409 - 413

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Citation Number: 28

Abstract

On the other hand, the cheaper (R)-isopropylidene-glyceraldehyde (11) 18 is the starting material when the C 5 unit is to be elaborated from the aldehyde function (Scheme 2). The formyl group was transformed into a benzyloxycarbonylaminomethyl function 12. A sequence of clean reactions via 13 gave the protected isoserine aldehyde 14 and the didehydroamino acid derivative 15 (E< 2%) was subsequently obtained by condensation ...

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