3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity

P Yogeeswari, R Thirumurugan, R Kavya…

Index: Yogeeswari, Perumal; Thirumurugan, Rathinasabapathy; Kavya, Ramkumar; Samuel, Jayakar Selwyn; Stables, James; Sriram, Dharmarajan European Journal of Medicinal Chemistry, 2004 , vol. 39, # 8 p. 729 - 734

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Citation Number: 43

Abstract

A series of 3-chloro-2-methylphenyl substituted semicarbazones (3–33) was synthesized and evaluated for anticonvulsant and CNS activities. After intraperitoneal injection to mice or rats, the semicarbazone derivatives were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), and subcutaneous strychnine (scSTY)- induced seizure and neurotoxicity screens. The aryl urea (1) and the semicarbazide (2) ...