A short and efficient synthesis of crocetin-dimethylester and crocetindial

D Frederico, PM Donate, MG Constantino…

Index: Frederico, Daniel; Marcos Donate, Paulo; Gomes Constantino, Mauricio; Soares Bronze, Erika; Sairre, Mirela I. Journal of Organic Chemistry, 2003 , vol. 68, # 23 p. 9126 - 9128

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Citation Number: 26

Abstract

In this paper we describe an efficient six-step synthesis of crocetin-dimethylester that could be further reduced to a “four-step” synthesis through the use of in situ procedures. The simplicity of the whole process, the ready availability of starting materials, and the high overall yield render this strategy a very attractive synthesis of this very important compound, which is the key intermediate for the synthesis of several carotenoids and other polyene ...