Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl) cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters

K Gingras, H Avedissian, E Thouin, V Boulanger…

Index: Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934

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Citation Number: 16

Abstract

The influence of stereochemistry and alkyl side chain length on the bioactivity of the Rho kinase inhibitor Y-27632 [(+)-1, R= Me] was examined by the synthesis of (+)-and (−)-1, and two alkyl chain analogs (+)-and (−)-2 (R= n-propyl) and (−)-3 (R= n-octyl) as well as their evaluation in enzymatic and neurite outgrowth assays.