Synthesis of second-generation Sansalvamide A derivatives: Novel templates as potential antitumor agents

…, JD Brown, J Cajica, E Parry, K Otrubova…

Index: Rodriguez, Rodrigo A.; Pan, Po-Shen; Pan, Chung-Mao; Ravula, Suchitra; Lapera, Stephanie; Singh, Erinprit K.; Styers, Thomas J.; Brown, Joseph D.; Cajica, Julia; Parry, Emily; Otrubova, Katerina; McAlpine, Shelli R. Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 1980 - 2002

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Citation Number: 45

Abstract

We report the synthesis of 34 second-generation Sansalvamide A derivatives. San A derivatives have unique anticancer properties and target multiple cancers, including colon, pancreatic, breast, prostate, and melanoma. As novel templates, the derivatives described herein explore the role of stereochemistry, amide bond geometry, transannular hydrogen bonding, and polarity on antitumor potency. Testing the chemotherapeutic activity of these ...

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