Synthesis, crystal structure, and coordination properties of a helical peptide having β-(3-pyridyl)-l-alanine and l-glutamic acid residues

…, M Ohama, N Ueyama, K Yamada, R Katakai

Index: Oku, Hiroyuki; Kimura, Yosuke; Ohama, Mitsuo; Ueyama, Norikazu; Yamada, Keiichi; Katakai, Ryoichi Journal of Organometallic Chemistry, 2007 , vol. 692, # 1-3 p. 79 - 87

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Citation Number: 2

Abstract

A novel helical peptide containing β-(3-pyirdyl)-l-alanine (Pal) and l-glutamic acid (Glu) residues has been designed and successfully prepared as a model ligand of metalloenzyme active sites. The helical peptide, Boc-Leu-Aib-Glu-Leu-Leu-Pal-Aib-Leu-OEt (1)(Boc= tert- butoxycarbonyl, Aib= 2-aminoisobutylic acid) yields fine crystals as an acetnitrile solvate. The metal ion binding affinities of 1 were tested for CoCl2 using UV/vis, CD, Raman, and ...

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