Efficient synthesis of secondary carboxamides with. OMEGA.-substituted ethyl and propyl groups on nitrogen atom by nucleophilic ring opening of cyclic imidates.

S Saito, H Tamai, Y Usui, M Inaba, T Moriwake

Index: Saito, Seiki; Tamai, Hideaki; Usui, Yuki; Inaba, Masami; Moriwake, Toshio Chemistry Letters, 1984 , p. 1243 - 1246

Full Text: HTML

Citation Number: 11

Abstract

An efficient synthesis of secondary carboxamides carrying ω-substituted ethyl and propyl groups on nitrogen atom has been developed which highlights nucleophilic ring opening of 2-methyl-2-oxazoline, 2-methyl-2-oxazine, and their derivatives with (CH 3) 3 SiX and HX (X= Cl, N 3, SeC 6 H 5, SC 6 H 5) type reagents.