Synthesis and biological evaluation of derivatives of 2-{2-Fluoro-4-[(2-oxocyclopentyl) methyl] phenyl} propanoic acid: nonsteroidal anti-inflammatory drugs with low …

N Yamakawa, S Suemasu, Y Okamoto…

Index: Yamakawa, Naoki; Suemasu, Shintaro; Okamoto, Yoshinari; Tanaka, Ken-Ichiro; Ishihara, Tomoaki; Asano, Teita; Miyata, Keishi; Otsuka, Masami; Mizushima, Tohru Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5143 - 5150

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Citation Number: 11

Abstract

We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) without selectivity for COX-2. We synthesized derivatives of 2-fluoroloxoprofen and studied their properties. Compared to 2- ...