Efficient synthesis of the 3'-phenolic metabolite of paclitaxel

SH Krishna Reddy, S Lee, A Datta…

Index: Reddy, S. Hari Krishna; Lee, Stephen; Datta, Apurba; Georg, Gunda I. Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8211 - 8214

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Citation Number: 23

Abstract

Paclitaxel (1; Taxol) and docetaxel (2; Taxotere) have emerged as two of the most effective antitumor agents in a variety of malignancies. 1-5 Acting via a similar mechanism of action, both these drugs bind to tubulin, leading to microtubule stabilization, mitotic arrest, and subsequent cell death. Despite the great similarity in the chemical structures and their mode of action, the metabolic profile of paclitaxel and docetaxel was found to be quite different. ...