N-thiolated β-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus

…, B Heldreth, TE Long, S Jang, E Turos

Index: Revell, Kevin D.; Heldreth, Bart; Long, Timothy E.; Jang, Seyoung; Turos, Edward Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2453 - 2467

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Citation Number: 30

Abstract

This study focuses on the mechanism of action of N-alkylthio β-lactams, a new family of antibacterial compounds that show promising activity against Staphylococcus and Bacillus microbes. Previous investigations have determined that these compounds are highly selective towards these bacteria, and possess completely unprecedented structure–activity profiles for a β-lactam antibiotic. Unlike penicillin, which inhibits cell wall crosslinking ...