Synthesis and evaluation of the affinity toward μ-opioid receptors of atypical, lipophilic ligands based on the sequence c [-Tyr-Pro-Trp-Phe-Gly-]

…, M Calienni, AR Qasem, S Spampinato

Index: Cardillo, Giuliana; Gentilucci, Luca; Tolomelli, Alessandra; Qasem, Ahmed R; Spampinato, Santi; Calienni, Maria Organic and biomolecular chemistry, 2003 , vol. 1, # 17 p. 3010 - 3014

Full Text: HTML

Citation Number: 41

Abstract

An ultimate and general model describing the interaction between opioid ligands and μ- opioid receptors is not available yet, so the mode of action of atypical peptide analogues or peptidomimetics is worthy of investigation. In this context, the peptide c [-Tyr-d-Pro-d-Trp- Phe-Gly-] was observed to act as an agonist toward μ-opioid receptors with appreciable potency, albeit deprived of a protonable nitrogen. This compound was synthesized as a ...

Related Articles:

Selective N-benzylation of amino acids under homogeneously catalyzed hydrogenation conditions

[Tararov, Vitali I.; Kadyrov, Renat; Fischer, Christine; Boerner, Armin Synlett, 2004 , # 11 p. 1961 - 1962]

The first enantioselective total syntheses of the allopumiliotoxin A alkaloids 267A and 339B

[Goldstein, Steven W.; Overmann, Larry E.; Rabinowitz, Michael H. Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1179 - 1190]

Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline

[Stapon, Anthony; Li, Rongfeng; Townsend, Craig A. Journal of the American Chemical Society, 2003 , vol. 125, # 28 p. 8486 - 8493]

… acids via copper (II) complexes of their Schiff bases with (S)-2-N-(N'-benzylprolyl) aminobenzaldehyde and (S)-2-N-(N'-benzylprolyl) aminoacetophenone. Crystal and …

[Belokon', Yu. N.; Zel'tzer, I. E.; Bakhmutov, V. I.; Saporovskaya, M. B.; Ryzhov, M. G.; et al. Journal of the American Chemical Society, 1983 , vol. 105, # 7 p. 2010 - 2017]

The first enantioselective total syntheses of the allopumiliotoxin A alkaloids 267A and 339B

[Journal of Organic Chemistry, , vol. 57, # 4 p. 1179 - 1190]

More Articles...