Synthesis of benzimidazole derivatives as antiallergic agents with 5-lipoxygenase inhibiting action.

H Nakano, T Inoue, N Kawasaki, H Miyataka…

Index: Nakano, Hiroyuki; Inoue, Tsutomu; Kawasaki, Nobuhide; Miyataka, Hideki; Matsumoto, Hitoshi; Taguchi, Takeo; Inagaki, Naoki; Nagai, Hiroichi; Satoh, Toshio Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1573 - 1578

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Citation Number: 75

Abstract

Syntheses were conducted of novel benzimidazole derivatives that suppress histamine release from mast cells, inhibit 5-lipoxygenase, and possess antioxidative action. Among the compounds synthesized, 1-[2-[2-(4-hydroxy-2, 3, 5-trimethylphenoxy) ethoxy] ethyl]-2-(4- methyl-1-homopiperazino) benzimidazole (22) potently suppressed histamine release from rat peritoneal mast cells triggered by the antigen-antibody reaction, inhibited 5- ...