Analogs of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone

…, PE Sum, CA Kohler, BM Goldstein

Index: Wissner, A.; Schaub, R. E.; Sum, P.-E.; Kohler, C. A.; Goldstein, B. M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1181 - 1187

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Citation Number: 16

Abstract

10 of analogues that incorporate alterations of the glycerine backbone of the molecule. Specifically, we report the syntheses and biological activities of racemic analogues in which the glycerine backbone has been substituted at the C1 or C3 carbon atoms with methyl groups and molecules in which the length of the backbone has been increased by the addition of a methylene group between the Cl-C2 or C2-C3 bonds.