Synthesis of deterium labeled plant ethylene precursor

KC Nam, H Rapoport

Index: Nam; Rapoport Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 5 p. 431 - 437

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Citation Number: 2

Abstract

Abstract Synthetic methods for the preparation of β-deuterium labeled 2-keto-4-methylbutyric acid were investigated. Vinyl chloride was first reacted with the ethyl oxalyl chloride moiety using aluminum chloride as condensing agent and the addition of methyl mercaptan followed. Deuterium labeling was achieved by using NaBD 4 reduction in pyridine.