Spontaneous membrane fusion induced by chemical formation of ceramides in a lipid bilayer

…, K Matsuoka, J Nishida, M Kanamori…

Index: Kunishima, Munetaka; Tokaji, Masafumi; Matsuoka, Keisuke; Nishida, Jin; Kanamori, Masanori; Hioki, Kazuhito; Tani, Shohei Journal of the American Chemical Society, 2006 , vol. 128, # 45 p. 14452 - 14453

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Citation Number: 21

Abstract

Mere chemical generation of ceramide and related double-chain lipids in the membrane of small unilamellar vesicles (SUVs) induces fusion of the vesicles. The lipids can be successfully prepared by dehydrocondensation between single-chain lipids (fatty acids and sphingosine or its analogues) in a lipid bilayer of the SUV by using a combination of 2- chloro-4, 6-dimethoxy-1, 3, 5-triazine and amphiphilic tertiary amine catalysts, a process ...