New class of β-aminoalcohol ligands derived from isosorbide and isomannide: application in hydrogen transfer reduction of prochiral ketones

TT Le, S Guillarme, C Saluzzo

Index: Le, Tin Thanh; Guillarme, Stephane; Saluzzo, Christine Tetrahedron, 2010 , vol. 66, # 46 p. 8893 - 8898

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Citation Number: 7

Abstract

Starting from isosorbide and isomannide, two by-products from the starch industry, a family of chiral functionalized β-aminoalcohols presenting a THF ring has been synthesized as potential ligands for hydrogen transfer reduction of prochiral ketones. Under optimal conditions, more than 70% ee with an excellent conversion were obtained for the HTR of the acetophenone.