Optimized synthesis of phosphatidylserine
G Guanti, L Banfi, A Basso, L Bondanza, G Guglieri…
Index: Guanti, Giuseppe; Banfi; Basso; Bondanza; Guglieri; Powles; Riva Amino Acids, 2010 , vol. 39, # 2 p. 367 - 373
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Citation Number: 4
Abstract
Abstract The synthesis of phosphatidyl serine containing saturated fatty acids was thoroughly studied and optimized in order to establish a protocol amenable to large-scale synthesis. The key step was a one-pot multicomponent reaction involving an O-benzyl phosphorodiamidite, protected serine and diacylglycerol, followed by in situ oxidation of the resulting phosphite. In order to replace expensive and poorly stable tetrazole, a screening ...
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