Helvetica chimica acta

Enantioselective Reduction of Electrophilic C C Bonds with sodium tetrahydroborate and 'semicorrin'cobalt catalysts

M Misun, A Pfaltz

Index: Misun, Marian; Pfaltz, Andreas Helvetica Chimica Acta, 1996 , vol. 79, # 4 p. 961 - 972

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Citation Number: 51

Abstract

Abstract 'Semicorrin'cobalt complexes, prepared in situ from cobalt (II) chloride and the corresponding ligands, are efficient catalysts for the enantioselective reduction of electrophilic C [DOUBLE BOND] C bonds with NaBH 4. The best selectivities (> 90% ee) are achieved with α, β-unsaturated carboxamides and carboxylates. Analogous α, β-unsaturated nitriles, sulfones, and phosphonates afford enantiomeric excesses of 50–70%. ...