Synthesis of SHIP1??Activating Analogs of the Sponge Meroterpenoid Pelorol

…, T MacRury, BO Patrick, A Ming??Lum…

Index: Meimetis, Labros G.; Nodwell, Matt; Yang, Lu; Wang, Xiaoxia; Patrick, Brian O.; Andersen, Raymond J.; Wu, Joyce; Harwig, Curtis; Stenton, Grant R.; MacKenzie, Lloyd F.; MacRury, Thomas; Ming-Lum, Andrew; Ong, Christopher J.; Mui, Alice L. -F.; Krystal, Gerald European Journal of Organic Chemistry, 2012 , # 27 p. 5195 - 5207,13

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Citation Number: 6

Abstract

Abstract Two biomimetic approaches have been used to synthesize analogs of the SHIP1- activating sponge meroterpenoid pelorol (1). One approach started from the chiral pool plant natural product sclareolide, which has the same absolute configuration as pelorol. The second approach utilized an enantioselective polyene cyclization to efficiently access both absolute configurations of the pelorol meroterpenoid skeleton and to prepare A-ring ...