Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives

T Calogeropoulou, P Angelou, A Detsi…

Index: Calogeropoulou, Theodora; Angelou, Panagiotis; Detsi, Anastasia; Fragiadaki, Irene; Scoulica, Effie Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 897 - 908

Full Text: HTML

Citation Number: 23

Abstract

Two series of novel ether phospholipids (EPs) have been synthesized. The first includes cyclodecylidene-or cyclopentadecylidene-substituted EPs carrying N, N, N- trimethylammonium or N-methylpiperidino or N-methylmorpholino head groups. The second series encompasses more rigid head groups in combination with cycloalkylidene moieties in the lipid portion. In addition, hydrogenated derivatives were obtained. All the new ...

Related Articles:

Convergent, short synthesis of the muscarinic superagonist iperoxo

[Kloeckner, Jessica; Schmitz, Jens; Holzgrabe, Ulrike Tetrahedron Letters, 2010 , vol. 51, # 27 p. 3470 - 3472]

Aminomethylation of acetylene alcohols and their esters with gem-diamines catalyzed by complexes of d-transition and rare-earth metals

[Shaibakova; Titova; Ibragimov; Dzhemilev Russian Journal of Organic Chemistry, 2011 , vol. 47, # 2 p. 161 - 167]

Transformations of dialkyl (4-hydroxy-2-butynyl)-(3-phenylallyl) ammonium bromides in an KOH aqueous solution or in the presence of powdered KOH

[Chukhadjian; Gabrielyan; Shahkhatuni; Panosyan Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 4 p. 418 - 424]

More Articles...