Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins

…, K Herath, JN Kahn, P Mann, G Abruzzo…

Index: Singh, Sheo B.; Herath, Kithsiri; Kahn, Jennifer Nielsen; Mann, Paul; Abruzzo, George; Motyl, Mary Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3253 - 3256

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Citation Number: 4

Abstract

Echinocandins and pneumocandins are classes of lipocyclohexapeptides that are broad spectrum antifungal agents. They inhibit fungal specific 1, 3-β-glucan synthase activity which is an essential component of the fungal cell wall. Chemical modifications of these two ...