Preparation of N-methoxycarbonyl-N′-[2-nitro-4 (5)-propylthiophenyl] thiourea as prodrugs of albendazole

…, G Martínez-Vázquez, R Morales-Hurtado…

Index: Hernandez-Luis, Francisco; Castillo, Rafael; Yepez-Mulia, Lilian; Cedillo-Rivera, Roberto; Martinez-Vazquez, Gabriel; Morales-Hurtado, Raul; Jung, Helgi; Sanchez, Monica; Hernandez-Campos, Alicia; Viveros, Noemi; Munoz, Onofre Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 18 p. 2231 - 2236

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Citation Number: 12

Abstract

N-methoxycarbonyl-N′-(2-nitro-4-propylthiophenyl) thiourea and N-methoxycarbonyl-N′- (2-nitro-5-propylthiophenyl) thiourea, prodrugs of albendazole, have been synthesized. The biotransformation in rats, after oral administration of these prodrugs to albendazole and albendazole sulphoxide, is described.