Tetrahedron

On the metalation of 3-substituted and 3, 6-disubstituted pyridazines

…, G Quéguiner, N Haider, H Schuller, G Heinisch

Index: Turck, Alain; Ple, Nelly; Ndzi, Bruno; Queguiner, Guy; Haider, Norbert; Schuller, Herbert; Heinisch, Gottfried Tetrahedron, 1993 , vol. 49, # 3 p. 599 - 606

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Citation Number: 58

Abstract

metalation, pyradazines, lithiation Starting from 3, 6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1–5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.