Elongated multiple electronic cascade and cyclization spacer systems in activatible anticancer prodrugs for enhanced drug release

…, C Albrecht, P de Bruijn, HW Scheeren

Index: De Groot; Loos; Koekkoek; Van Berkom; Busscher; Seelen; Albrecht; De Bruijn; Scheeren Journal of Organic Chemistry, 2001 , vol. 66, # 26 p. 8815 - 8830

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Citation Number: 102

Abstract

The design and synthesis of several novel elongated self-elimination spacer systems for application in prodrugs is described. These elongated spacer systems can be incorporated between a cleavable specifier and the parent drug. Naphthalene-and biphenyl-containing spacers were synthesized but did not eliminate. Prodrugs of the anticancer agents doxorubicin and paclitaxel are reported that contain two or three electronic cascade ...