A ratiometric fluorescent pH probe based on aggregation-induced emission enhancement and its application in live-cell imaging

P Song, X Chen, Y Xiang, L Huang, Z Zhou…

Index: Song, Panshu; Chen, Xiaotong; Xiang, Yu; Huang, Lei; Zhou, Zhaojuan; Wei, Ruirui; Tong, Aijun Journal of Materials Chemistry, 2011 , vol. 21, # 35 p. 13470 - 13475

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Citation Number: 57

Abstract

A ratiometric fluorescent pH probe, 4-carboxylaniline-5-chlorosalicylaldehyde Schiff base (1) was synthesized via a facile reaction and used for pH sensing in live cells. While exhibiting weak fluorescence when dispersed in solution, 1 displayed aggregation-induced emission enhancement (AIEE) characteristics in its aggregate/solid state, as a result of the restriction of free intramolecular rotation of a C–N bond and the non-planar configuration in the ...