The origin of the β-lactam carbons of clavulanic acid

…, JE Baldwin, JP Griffin, CJ Schofield

Index: Thirkettle, Jan E.; Baldwin, Jack E.; Edwards, Jeff; Griffin, John P.; Schofield, Christopher J. Chemical Communications, 1997 , # 11 p. 1025 - 1026

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Citation Number: 21

Abstract

Clavulanic acid 1 is a commercially important inhibitor of b- lactamases, and is produced via fermentation of Streptomyces clavuligerus. It is known that the primary metabolic precursor of the five-carbon unit (Scheme 1) of clavulanic acid is arginine,1 Pioneering studies by Elson et al.2 and Townsend et al.3 have demonstrated that the precursor of the three-carbon unit is a three-carbon primary metabolite (both pyruvate2 and glycerate3 have been proposed) ...