A Catalytic Asymmetric Reaction Involving Enolizable Anhydrides
C Cornaggia, F Manoni, E Torrente, S Tallon…
Index: Cornaggia, Claudio; Manoni, Francesco; Torrente, Esther; Tallon, Sean; Connon, Stephen J. Organic Letters, 2012 , vol. 14, # 7 p. 1850 - 1853
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Citation Number: 23
Abstract
In the presence of a highly efficient novel bifunctional organocatalyst at low loadings under mild conditions, enolizable homophthalic anhydrides can be added to a range of aromatic and aliphatic aldehydes to give dihydroisocoumarins, with excellent yields and diastereo- and enantiocontrol (up to 99% ee).
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