Neopeptide antibiotics that function as opsonins and membrane-permeabilizing agents for gram-negative bacteria

…, S Cohen, T Giterman, A Matityahou…

Index: Tsubery, Haim; Yaakov, Hertzig; Cohen, Sofia; Giterman, Tal; Matityahou, Ariella; Fridkin, Mati; Ofek, Itzhak Antimicrobial Agents and Chemotherapy, 2005 , vol. 49, # 8 p. 3122 - 3128

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Citation Number: 33

Abstract

ABSTRACT We suggest a novel approach to enhancing antimicrobial drug action by utilizing engineered peptide conjugates. Our most potent conjugates,[fMLF] PMBN and [fMLF] PMEN, are nonapeptides derived from polymyxin B's (PMB's) cyclic moiety (Thr-Dab- cyclo [Dab-Dab-d-Phe-Leu-Dab-Dab-Thr], where Dab is 2, 4-diaminobutyric acid) and polymyxin E's (PME's) cyclic moiety (Thr-Dab-cyclo [Dab-Dab-d-Leu-Leu-Dab-Dab-Thr]), ...