Bioorganic & medicinal chemistry

Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives

M Yusuf, RA Khan, B Ahmed

Index: Yusuf, Mohammad; Khan, Riaz A.; Ahmed, Bahar Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 17 p. 8029 - 8034

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Citation Number: 88

Abstract

A number of new imine derivatives of 5-amino-1, 3, 4-thiadiazole-2-thiol have been synthesized, and their anti-depressant activity was tested using imipramine as reference drug. Two compounds namely 5-{[1-(4-chlorophenyl)-3-(4-methoxy-phenyl) prop-2-en-1- ylidene]-amino}-5-benzylthio-1, 3, 4-thiadiazole 4i (b) and 5-{[1-(4-chlorophenyl)-3-(4- dimethyl-aminophenyl)-prop-2-en-1-ylidene] amino}-5-benzylthio-1, 3, 4-thiadiazole 4i (c) ...