Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases

…, M Pocci, F Lucchesini, A De Munno

Index: De Munno, Angela; Bertini, Vincenzo; Picci, Nevio; Iemma, Francesca; Pocci, Marco Heterocycles, 1996 , vol. 43, # 9 p. 1893 - 1900

Full Text: HTML

Citation Number: 15

Abstract

The first substratelike, reversible inhibitors of different copper amine oxidases (CAOs) with IC50 (M) as low as 2.0× 10-8 corresponding to derivatives of 4-aminomethylpyridine with alkoxy (1a-d), alkylthio (2a, b), and alkylamino (3a-e, 4a-j) groups in the positions 3 and 5 have been prepared and studied. The inhibitors 1a-d are active on benzylamine oxidase and semicarbazide-sensitive amine oxidase and are very selective with respect to ...