Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT 1A partial agonists

…, C Coleman, EM Collantes, L Denny, S Dutta…

Index: Dounay, Amy B.; Barta, Nancy S.; Campbell, Brian M.; Coleman, Corey; Collantes, Elizabeth M.; Denny, Lynne; Dutta, Satavisha; Gray, David L.; Hou, Dongfeng; Iyer, Rathna; Maiti, Samarendra N.; Ortwine, Daniel F.; Probert, Al; Stratman, Nancy C.; Subedi, Rajendra; Whisman, Tammy; Xu, Wenjian; Zoski, Kim Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1114 - 1117

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Citation Number: 3

Abstract

Preclinical studies suggest that compounds with dual norepinephrine reuptake inhibitor (NRI) and 5-HT1A partial agonist properties may provide an important new therapeutic approach to ADHD, depression, and anxiety. Reported herein is the discovery of a novel chemical series with a favorable NRI and 5-HT1A partial agonist pharmacological profile as well as excellent selectivity for the norepinephrine transporter over the dopamine ...