Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

…, CG Caldwell, RJ Mathvink, B Leiting, F Marsilio…

Index: Chen, Ping; Caldwell, Charles G.; Mathvink, Robert J.; Leiting, Barbara; Marsilio, Frank; Patel, Reshma A.; Wu, Joseph K.; He, Huaibing; Lyons, Kathryn A.; Thornberry, Nancy A.; Weber, Ann E. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 5853 - 5857

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Citation Number: 18

Abstract

A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1-and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC50 values as low as 5.8 nM for inhibition of DPP-4.