Nucleosides & nucleotides

Effect of Acridine with Various Linker Arms Attached to C5 Position of 2′-Deoxyuridine on the Stability of DNA/DNA and DNA/RNA Duplexes

H Ozaki, Y Ogawa, M Mine, H Sawai*

Index: Ozaki, Hiroaki; Ogawa, Yoshinori; Mine, Masayuki; Sawai, Hiroaki Nucleosides and Nucleotides, 1998 , vol. 17, # 5 p. 911 - 923

Full Text: HTML

Citation Number: 9

Abstract

Abstract Acridine-modified oligodeoxyribonucleotides (ODNs) at the C5-position of a 2′- deoxyuridine via different lengths of linker arms were synthesized. Reaction of 5-(N- aminoalkyl) carbamoylmethyl-2′-deoxyuridines with 9-phenoxyacridine gave the acridine- modified 2′-deoxyuridines which were incorporated into ODNs. The duplexes containing the acridine-modified strands and their complementary DNA or RNA were thermally more ...