Isopropyl amide derivatives of potent and selective muscarinic M 2 receptor antagonists

…, S Dugar, JW Clader, WJ Greenlee, V Ruperto…

Index: Palani, Anandan; Dugar, Sundeep; Clader, John W.; Greenlee, William J.; Ruperto, Vilma; Duffy, Ruth A.; Lachowicz, Jean E. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1791 - 1794

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Citation Number: 8

Abstract

Low molecular weight amide derivatives were synthesized and evaluated as M2 receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M2 receptor antagonists with structural features different from our clinical candidate 1.