Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1, 3-benzoxazines and DNA-PK and PI3K inhibition, …

…, JMA Al-Rawi, CJ Bradley, MJ Angove…

Index: Ihmaid, Saleh K.; Al-Rawi, Jasim M.A.; Bradley, Christopher J.; Angove, Michael J.; Robertson, Murray N. European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 85 - 101

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Citation Number: 25

Abstract

A number of new 2-(pyridin-3-ylamino)-4H-(substituted) benz [e]-1, 3-oxazin-4-ones were synthesized 10a–g. These were then reacted with the hydro-halogen salt of 2, 3 and 4-(halo- methyl) pyridine in the presence of Cs2CO3 to give eighteen new 2-(N-substituted (pyridin-3- ylmethyl) amino)-substituted-1, 3-benzoxazines (compounds 11a–i, 13a–c, and 15a–f). X- ray crystallography was used to confirm that the 2-N-substituted structures 11 and 13 were ...