Bi (OTf) 3-catalyzed Regioselective Ring Opening of Epoxides with Phenols: Facile Synthesis of 1, 3-Diaryloxy-2-propanols

A Kamal, SK Ahmed, M Sandbhor, MN Ahmed Khan…

Index: Kamal, Ahmed; Ahmed, Syed Kaleem; Sandbhor, Mahendra; Khan, Mohammed Naseer Ahmed; Arifuddin, Mohammed Chemistry Letters, 2005 , vol. 34, # 8 p. 1142 - 1143

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Citation Number: 14

Abstract

Substituted aryl oxiranes undergo the facile ring opening with phenols in the presence of catalytic amount of bismuth (III) triflate to afford 1, 3-diaryloxy-2-propanols in excellent yields under mild conditions. Bismuth (III) triflate is relatively non-toxic, easy to handle and inexpensive, which makes this procedure particularly attractive for large scale synthesis.

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