The Journal of Organic Chemistry

Studies on the reactivity of bicyclomycin with nucleophilic amino acid derivatives

S Abuzar, H Kohn

Index: Abuzar, Syed; Kohn, Harold Journal of Organic Chemistry, 1989 , vol. 54, # 16 p. 4000 - 4003

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Citation Number: 16

Abstract

Bicyclomycin (1) is a clinically useful antibiotic marketed under the trade name Bicozamycin. Its unique structure and broad spectrum of antimicrobial activity have contributed to the increasing interest in this drug." 15 Biochemical studies indicate that 1 binds with select bacterial inner-membrane proteins (ie, sulfhydryl-containing residues) leading to the disruption of cell wall gr~ wth.~ Controversy exists as to whether drug activation occurs by ...

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