Step??Economical Synthesis of Taxol??like Tricycles through a Palladium??Catalyzed Domino Reaction

J Petrignet, A Boudhar, G Blond…

Index: Petrignet, Julien; Boudhar, Aicha; Blond, Gaelle; Suffert, Jean Angewandte Chemie - International Edition, 2011 , vol. 50, # 14 p. 3285 - 3289

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Citation Number: 26

Abstract

The world of natural bioactive products offers a large variety of structurally complex molecules.[1] Two main factors slow their study and clinical advancement: 1) the scarcity and variability of the natural sources and 2) their availability by synthesis which often requires many steps and therefore time and effort. In contrast, knowledge of how a natural product functions could allow for the design of simpler, more synthetically accessible, and ...

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