… ) ethyl-6-(pyrrolidin-1-yl)-1, 3, 5-triazine-2, 4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher …

…, J Inglese, E Sidransky, CP Austin, CJ Thomas

Index: Huang, Wenwei; Zheng, Wei; Urban, Daniel J.; Inglese, James; Sidransky, Ellen; Austin, Christopher P.; Thomas, Craig J. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 5783 - 5789

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Citation Number: 24

Abstract

Glycosphingolipids are cell membrane components that maintain the stability of the lipid bilayer, function as cellular recognition elements and play an important role in cellular adherence. 1 These important cellular constructs are comprised of varying polysaccharide chains linked to ceramide via a glycosidic bond. Glycosphingolipids are ultimately targeted for degradation through the action of selected lysosomal hydrolases. 2 Several different diseases arise ...