Synthesis of new potential HIV-1 integrase inhibitors

…, ML Barreca, M Witvrouw, Z Debyser, P Monforte

Index: Ferro, Stefania; Rao, Angela; Zappala, Maria; Chimirri, Alba; Letizia Barreca, Maria; Witvrouw, Myriam; Debyser, Zeger; Monforte, Pietro Heterocycles, 2004 , vol. 63, # 12 p. 2727 - 2734

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Citation Number: 21

Abstract

Abstract: A synthesis of some 1, 2-(hetero) arylsubstituted ethanone and 1, 3 (hetero) aryl substituted 3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported. The microwave-assisted synthesis was applied in several reactions achieving reductions in reaction times and high yields. All compounds prepared were tested to explore their potential anti-HIV activity.

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